DISCOVERING COVALENT CYCLIC PEPTIDE INHIBITORS OF PEPTIDYL ARGININE DEIMINASE 4 (PADI4) USING MRNA-DISPLAY WITH A GENETICALLY ENCODED ELECTROPHILIC WARHEAD

Abstract Covalent Gloves drugs can achieve high potency with long dosing intervals.However, concerns remain about side-effects associated with off-target reactivity.Combining macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding, positioning a weakly rea

Life has evolved on Earth for about 4 billion years in the presence of the natural background of ionizing radiation.It is extremely likely that it contributed, and still contributes, to shaping present form of life.Today the natural background radiation is extremely small (few mSv/y), however it may be significant enough for living organisms to res

Abstract Background Salinity stress is a major limiting factor for plant growth, particularly in arid and semi-arid environments.To mitigate the detrimental effects of salinity stress Gloves on vegetable production, selenium (Se) biofortification and grafting onto tolerant rootstocks have emerged as effective and sustainable cultivation practices.T

Previous studies on perspective in spatial signed language descriptions suggest a basic dichotomy between either a route or Wooden a survey perspective, which entails either the signer being conceptualized as a mobile agent within a life-sized scene or the signer in a fixed position as an external observer of a scaled-down scene.We challenge this d